Gene name:
JAK1 (JAK1A;JAK1B) ;
Protein name:
Tyrosine-protein kinase JAK1 ;
Alternative:
Janus kinase 1 (JAK-1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB.
Function:
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Subcellular Location:
Endomembrane system
Peripheral membrane protein
Wholly intracellular, possibly membrane associated.
Protein Attributes:
50:
MQYLNIKEDC | NAMAFCAKMR | SSKKTEVNLE | APEPGVEVIF | YLSDREPLRL |
100:
GSGEYTAEEL | CIRAAQACRI | SPLCHNLFAL | YDENTKLWYA | PNRTITVDDK |
150:
MSLRLHYRMR | FYFTNWHGTN | DNEQSVWRHS | PKKQKNGYEK | KKIPDATPLL |
200:
DASSLEYLFA | QGQYDLVKCL | APIRDPKTEQ | DGHDIENECL | GMAVLAISHY |
250:
AMMKKMQLPE | LPKDISYKRY | IPETLNKSIR | QRNLLTRMRI | NNVFKDFLKE |
300:
FNNKTICDSS | VSTHDLKVKY | LATLETLTKH | YGAEIFETSM | LLISSENEMN |
350:
WFHSNDGGNV | LYYEVMVTGN | LGIQWRHKPN | VVSVEKEKNK | LKRKKLENKH |
400:
KKDEEKNKIR | EEWNNFSYFP | EITHIVIKES | VVSINKQDNK | KMELKLSSHE |
450:
EALSFVSLVD | GYFRLTADAH | HYLCTDVAPP | LIVHNIQNGC | HGPICTEYAI |
500:
NKLRQEGSEE | GMYVLRWSCT | DFDNILMTVT | CFEKSEQVQG | AQKQFKNFQI |
550:
EVQKGRYSLH | GSDRSFPSLG | DLMSHLKKQI | LRTDNISFML | KRCCQPKPRE |
600:
ISNLLVATKK | AQEWQPVYPM | SQLSFDRILK | KDLVQGEHLG | RGTRTHIYSG |
650:
TLMDYKDDEG | TSEEKKIKVI | LKVLDPSHRD | ISLAFFEAAS | MMRQVSHKHI |
700:
VYLYGVCVRD | VENIMVEEFV | EGGPLDLFMH | RKSDVLTTPW | KFKVAKQLAS |
750:
ALSYLEDKDL | VHGNVCTKNL | LLAREGIDSE | CGPFIKLSDP | GIPITVLSRQ |
800:
ECIERIPWIA | PECVEDSKNL | SVAADKWSFG | TTLWEICYNG | EIPLKDKTLI |
850:
EKERFYESRC | RPVTPSCKEL | ADLMTRCMNY | DPNQRPFFRA | IMRDINKLEE |
900:
QNPDIVSEKK | PATEVDPTHF | EKRFLKRIRD | LGEGHFGKVE | LCRYDPEGDN |
950:
TGEQVAVKSL | KPESGGNHIA | DLKKEIEILR | NLYHENIVKY | KGICTEDGGN |
1000:
GIKLIMEFLP | SGSLKEYLPK | NKNKINLKQQ | LKYAVQICKG | MDYLGSRQYV |
1050:
HRDLAARNVL | VESEHQVKIG | DFGLTKAIET | DKEYYTVKDD | RDSPVFWYAP |
1100:
ECLMQSKFYI | ASDVWSFGVT | LHELLTYCDS | DSSPMALFLK | MIGPTHGQMT |
1150:
VTRLVNTLKE | GKRLPCPPNC | PDEVYQLMRK | CWEFQPSNRT | SFQNLIEGFE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Tyrosine-protein kinase JAK1
ELISA Kit for Human Tyrosine-protein kinase JAK1
CLIA Kit for Human Tyrosine-protein kinase JAK1
CLIA Kit for Human Tyrosine-protein kinase JAK1
Polyclonal Antibody for Human Tyrosine-protein kinase JAK1
Polyclonal Antibody for Human Tyrosine-protein kinase JAK1
Monoclonal Antibody for Human Tyrosine-protein kinase JAK1
Monoclonal Antibody for Human Tyrosine-protein kinase JAK1
Protein for Human Tyrosine-protein kinase JAK1
Protein for Human Tyrosine-protein kinase JAK1
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
3.
"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G.
,
Barlow K.F.
,
McLay K.E.
,
Kaul R.
,
Swarbreck D.
,
Dunham A.
,
Scott C.E.
,
Howe K.L.
,
Woodfine K.
,
Spencer C.C.A.
,
Jones M.C.
,
Gillson C.
,
Searle S.
,
Zhou Y.
,
Kokocinski F.
,
McDonald L.
,
Evans R.
,
Phillips K.
,
Atkinson A.
,
Cooper R.
,
Jones C.
,
Hall R.E.
,
Andrews T.D.
,
Lloyd C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Anderson F.
,
Andrew R.W.
,
Ashwell R.I.S.
,
Aubin K.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Beasley H.
,
Bethel G.
,
Bird C.P.
,
Bray-Allen S.
,
Brown J.Y.
,
Brown A.J.
,
Buckley D.
,
Burton J.
,
Bye J.
,
Carder C.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.
,
Cobley V.
,
Collier R.E.
,
Corby N.
,
Coville G.J.
,
Davies J.
,
Deadman R.
,
Dunn M.
,
Earthrowl M.
,
Ellington A.G.
,
Errington H.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gay L.
,
Ghori M.R.J.
,
Gibson R.
,
Gilby L.M.
,
Gillett W.
,
Glithero R.J.
,
Grafham D.V.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Hammond S.
,
Harrison E.S.I.
,
Hart E.
,
Haugen E.
,
Heath P.D.
,
Holmes S.
,
Holt K.
,
Howden P.J.
,
Hunt A.R.
,
Hunt S.E.
,
Hunter G.
,
Isherwood J.
,
James R.
,
Johnson C.
,
Johnson D.
,
Joy A.
,
Kay M.
,
Kershaw J.K.
,
Kibukawa M.
,
Kimberley A.M.
,
King A.
,
Knights A.J.
,
Lad H.
,
Laird G.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
Lush M.J.
,
Lyne R.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Matthews N.S.W.
,
McLaren S.
,
Milne S.
,
Mistry S.
,
Moore M.J.F.
,
Nickerson T.
,
O'Dell C.N.
,
Oliver K.
,
Palmeiri A.
,
Palmer S.A.
,
Parker A.
,
Patel D.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phelps K.
,
Phillimore B.J.
,
Plumb R.
,
Rajan J.
,
Raymond C.
,
Rouse G.
,
Saenphimmachak C.
,
Sehra H.K.
,
Sheridan E.
,
Shownkeen R.
,
Sims S.
,
Skuce C.D.
,
Smith M.
,
Steward C.
,
Subramanian S.
,
Sycamore N.
,
Tracey A.
,
Tromans A.
,
Van Helmond Z.
,
Wall M.
,
Wallis J.M.
,
White S.
,
Whitehead S.L.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams H.
,
Wilming L.
,
Wray P.W.
,
Wu Z.
,
Coulson A.
,
Vaudin M.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Wooster R.
,
Dunham I.
,
Carter N.P.
,
McVean G.
,
Ross M.T.
,
Harrow J.
,
Olson M.V.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1005-1062
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1008-1062;TISSUE SPECIFICITY
tissue :
Colon tumor .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IFNAR2
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SHB
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN CYTOKINE SIGNALING;PHOSPHORYLATION AT TYR-1034 AND TYR-1035;DEPHOSPHORYLATION AT TYR-1034 AND TYR-1035 BY PTPN2
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IL31RA
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH JAKMIP1
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-3 AND SER-228;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 865-1154 IN COMPLEXES WITH SYNTHETIC INHIBITORS CMP6 AND CP-690,550
16.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] LYS-973